Инсулин

INS
Достапни структури PDB Ortholog search: PDBe RCSB Список на PDB id кодови 1A7F, 1AI0, 1AIY, 1B9E, 1BEN, 1EV3, 1EV6, 1EVR, 1FU2, 1FUB, 1G7A, 1G7B, 1GUJ, 1HIQ, 1HIS, 1HIT, 1HLS, 1HTV, 1HUI, 1IOG, 1IOH, 1J73, 1JCA, 1JCO, 1K3M, 1KMF, 1LKQ, 1LPH, 1MHI, 1MHJ, 1MSO, 1OS3, 1OS4, 1Q4V, 1QIY, 1QIZ, 1QJ0, 1RWE, 1SF1, 1T1K, 1T1P, 1T1Q, 1TRZ, 1TYL, 1TYM, 1UZ9, 1VKT, 1W8P, 1XDA, 1XGL, 1XW7, 1ZEG, 1ZEH, 1ZNJ, 2AIY, 2C8Q, 2C8R, 2CEU, 2H67, 2HH4, 2HHO, 2HIU, 2JMN, 2JUM, 2JUU, 2JUV, 2JV1, 2JZQ, 2K91, 2K9R, 2KJJ, 2KJU, 2KQQ, 2KXK, 2L1Y, 2L1Z, 2LGB, 2M1D, 2M1E, 2M2M, 2M2N, 2M2O, 2M2P, 2OLY, 2OLZ, 2OM0, 2OM1, 2OMG, 2OMH, 2OMI, 2QIU, 2R34, 2R35, 2R36, 2RN5, 2VJZ, 2VK0, 2W44, 2WBY, 2WC0, 2WRU, 2WRV, 2WRW, 2WRX, 2WS0, 2WS1, 2WS4, 2WS6, 2WS7, 3AIY, 3BXQ, 3E7Y, 3E7Z, 3EXX, 3FQ9, 3I3Z, 3I40, 3ILG, 3INC, 3IR0, 3Q6E, 3ROV, 3TT8, 3U4N, 3UTQ, 3UTS, 3UTT, 3V19, 3V1G, 3W11, 3W12, 3W13, 3W7Y, 3W7Z, 3W80, 3ZI3, 3ZQR, 3ZS2, 3ZU1, 4AIY, 4AJX, 4AJZ, 4AK0, 4AKJ, 4EFX, 4EWW, 4EWX, 4EWZ, 4EX0, 4EX1, 4EXX, 4EY1, 4EY9, 4EYD, 4EYN, 4EYP, 4F0N, 4F0O, 4F1A, 4F1B, 4F1C, 4F1D, 4F1F, 4F1G, 4F4T, 4F4V, 4F51, 4F8F, 4FG3, 4FKA, 4GBC, 4GBI, 4GBK, 4GBL, 4GBN, 4IUZ, 5AIY, 2LWZ, 3JSD, 3KQ6, 3P2X, 3P33, 1JK8, 2MLI, 2MPG, 2MPI, 2MVC, 2MVD, 4CXL, 4CXN, 4CY7, 4NIB, 4OGA, 4P65, 4Q5Z, 4RXW, 4UNE, 4UNG, 4UNH, 4XC4, 4WDI, 4Z76, 4Z77, 4Z78, 2N2W, 5CO6, 5ENA, 4Y19, 5BQQ, 5BOQ, 2N2V, 5CNY, 5CO9, 5EN9, 4Y1A, 2N2X, 5BPO, 5CO2, 5BTS, 5HYJ, 5C0D,%%s1EFE, 1SJT, 1SJU, 2KQP,%%s1T0C,%%s2G54, 2G56, 3HYD, 2OMQ
Идентификатори
Синоними	INS, IDDM, IDDM1, IDDM2, ILPR, IRDN, MODY10, insulin
External IDs	OMIM: 176730 MGI: 96573 HomoloGene: 173 GeneCards: INS
Локација на генот (кај човек) Chr. Chromosome 11 (human) Band 11p15.5 Start 2,159,779 bp End 2,161,341 bp
Локација на генот (кај глушец) Chr. Chromosome 7 (mouse) Band 7 F5|7 88.0 cM Start 142,678,656 bp End 142,743,381 bp
RNA expression pattern More reference expression data
Gene ontology Молекуларна функција • insulin receptor binding • identical protein binding • protease binding • insulin-like growth factor receptor binding • protein binding • hormone activity Клеточна компонента • endoplasmic reticulum lumen • transport vesicle • Golgi membrane • secretory granule lumen • Golgi lumen • endoplasmic reticulum-Golgi intermediate compartment membrane • endosome lumen • extracellular region • Q14325730 Биолошки процес • negative regulation of NAD(P)H oxidase activity • positive regulation of DNA replication • positive regulation of MAPK cascade • positive regulation of brown fat cell differentiation • positive regulation of cell differentiation • MAPK cascade • positive regulation of respiratory burst • positive regulation of cytokine secretion • positive regulation of phosphatidylinositol 3-kinase signaling • negative regulation of protein oligomerization • positive regulation of NF-kappaB transcription factor activity • negative regulation of respiratory burst involved in inflammatory response • cell-cell signaling • positive regulation of nitric oxide biosynthetic process • positive regulation of glycolytic process • positive regulation of nitric-oxide synthase activity • positive regulation of protein autophosphorylation • activation of protein kinase B activity • Заздравување на рана • positive regulation of mitotic nuclear division • negative regulation of feeding behavior • cellular protein metabolic process • positive regulation of peptide hormone secretion • negative regulation of protein catabolic process • positive regulation of cell migration • acute-phase response • regulation of protein secretion • positive regulation of glycogen biosynthetic process • positive regulation of protein kinase B signaling • G-protein coupled receptor signaling pathway • glucose transport • regulation of cellular amino acid metabolic process • negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway • ER to Golgi vesicle-mediated transport • negative regulation of lipid catabolic process • positive regulation of cell growth • negative regulation of glycogen catabolic process • positive regulation of insulin receptor signaling pathway • glucose metabolic process • negative regulation of acute inflammatory response • negative regulation of protein secretion • positive regulation of peptidyl-tyrosine phosphorylation • glucose homeostasis • positive regulation of cell proliferation • fatty acid homeostasis • positive regulation of cellular protein metabolic process • regulation of transmembrane transporter activity • negative regulation of gluconeogenesis • negative regulation of fatty acid metabolic process • regulation of protein localization • regulation of transcription, DNA-templated • positive regulation of lipid biosynthetic process • carbohydrate metabolic process • negative regulation of proteolysis • alpha-beta T cell activation • positive regulation of protein localization to nucleus • positive regulation of glucose import • insulin receptor signaling pathway • positive regulation of gene expression • positive regulation of blood vessel diameter • negative regulation of blood vessel diameter • regulation of receptor activity • positive regulation of nitric oxide mediated signal transduction • regulation of synaptic plasticity • спознание • positive regulation of long-term synaptic potentiation • positive regulation of dendritic spine maintenance • regulation of protein localization to plasma membrane • negative regulation of reactive oxygen species biosynthetic process • neuron projection maintenance • response to L-arginine • signal transduction Sources:Amigo / QuickGO
Orthologs
Видови	Човек	Глушец
Entrez	3630	16334
Ensembl	ENSG00000254647	ENSMUSG00000000215
UniProt	P01308	P01326
RefSeq (mRNA)	NM_000207 NM_001185097 NM_001185098 NM_001291897	NM_001185083 NM_001185084 NM_008387
RefSeq (protein)	NP_000198 NP_001172026 NP_001172027 NP_001278826 NP_000198.1 NP_001172026.1 NP_001172027.1 NP_001278826.1 NP_000198 NP_000198 NP_000198 NP_001172026 NP_001172027 NP_001278826 NP_000198 NP_000198	NP_001172012 NP_001172013 NP_032413
Location (UCSC)	Chr 11: 2.16 – 2.16 Mb	Chr 7: 142.68 – 142.74 Mb
PubMed search
Википодатоци
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Вијала со инсулин

Инсулинот (од латински, insula што значи остров) е хормон кој се секретира од панкреасот, поточно од бета- клетките од лангерхансовите островца. Главната и основна функција на инсулинот е намалување на концентрацијата на глукозата во крвта (хипогликемија). Исто така, инсулинот ја стимулира и синтезата на протеините.