Калцитонин

CALCA
Достапни структури PDB Human UniProt search: PDBe RCSB Список на PDB id кодови 2JXZ,%%s1LS7
Назнаки
Синоними	CALCA, CT, CGRP-I, CGRP-alpha, KC, PCT, calcitonin related polypeptide alpha, CGRP, CGRP1, CALC1
External IDs	OMIM: 114130 HomoloGene: 88401 GeneCards: CALCA
Наоѓалиште на генот (кај човек) Chr. Хромозом 11 (хуман) Band 11p15.2 Start 14,966,668 bp End 14,972,351 bp
RNA expression pattern More reference expression data
Gene ontology Молекуларна функција • hormone activity • calcitonin receptor binding • GO:0001948, GO:0016582 protein binding • identical protein binding • signaling receptor binding • GO:0032403 protein-containing complex binding Клеточна компонента • Цитоплазма • intracellular anatomical structure • extracellular region • живчено влакно • terminal bouton • neuronal cell body • neuron projection • клеточно јадро • extracellular space Биолошки процес • cellular response to nerve growth factor stimulus • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway • negative regulation of smooth muscle contraction • regulation of heart contraction • monocyte chemotaxis • negative regulation of blood pressure • positive regulation of cytosolic calcium ion concentration • cellular response to tumor necrosis factor • GO:0010260 ageing • вазодилатација • cellular calcium ion homeostasis • response to heat • negative regulation of nervous system process • positive regulation of ossification • activation of adenylate cyclase activity • regulation of heart rate • detection of temperature stimulus involved in sensory perception of pain • negative regulation of ossification • response to pain • artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure • прехранбено поведение • inflammatory response • neuropeptide signaling pathway • GO:0045996 negative regulation of transcription, DNA-templated • activation of protein kinase activity • embryo implantation • negative regulation of bone resorption • regulation of signaling receptor activity • G protein-coupled receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of cytosolic calcium ion concentration • leukocyte cell-cell adhesion • G protein-coupled receptor internalization • positive regulation of interleukin-1 alpha production • response to yeast • negative regulation of osteoclast differentiation • cell-cell signaling • antibacterial humoral response • positive regulation of macrophage differentiation • receptor internalization • regulation of blood pressure • protein phosphorylation • vasculature development • GO:0051636 defense response to Gram-negative bacterium • endothelial cell proliferation • positive regulation of interleukin-8 production • nervous system process involved in regulation of systemic arterial blood pressure • negative regulation of calcium ion transport into cytosol • Вроден имунолошки систем • endothelial cell migration • antifungal humoral response • GO:0051637 defense response to Gram-positive bacterium • antimicrobial humoral immune response mediated by antimicrobial peptide • amylin receptor signaling pathway • calcitonin gene-related peptide receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Видови	Човек	Глушец
Entrez	796	n/a
Ensembl	ENSG00000110680	n/a
UniProt	P06881	n/a
RefSeq (mRNA)	NM_001033952 NM_001033953 NM_001741 NM_001378949 NM_001378950	n/a
RefSeq (protein)	NP_001029125.1	n/a
Location (UCSC)	Chr 11: 14.97 – 14.97 Mb	n/a
PubMed search		n/a
Википодатоци
View/Edit Human

Калцитонин (или тирокалцитонин) е хормон кој се синтетизира од штитната жлезда, поточно од посебни клетки, наречени парафоликуларни клетки. Тој учествува во регулацијата на метаболизмот на калциум и фосфор. Калцитонинот стимулира вградување на калциум во коските и зголемување на концентрацијата на фосфор во крвта. Овој хормон има важна улога и во процесот на окоскувањето.